Thursday, October 10, 2013

A hopeful headline--and a spur to action

"Alzheimer’s treatment breakthrough: British scientists pave way for simple pill to cure disease"--that's the headline in The Independent (UK). 


Then, the fine print, as it were: "Although the prospect of a pill for Alzheimer's remains a long way off, the landmark British study provides a major new pathway for future drug treatments."  

And that should be our spur to action.

UPDATE: Jeremy Shane, a long-time medical observer living in Washington DC, adds these sage comments:

"First, it is critical for government funds to support ideas that seem out of the mainstream where mainstream ideas continue to disappoint.

"Second, figuring out a drug that "works" is only half the battle -- we need funds to figure out how to deliver drugs only to those places where they will be useful and not to places where they cause side-effects.  

"On the first point, Alzheimer's research for decades has focused on two competing causes of neuronal failure -- accumulation of beta-amyloid protein tangles or the malfunction of a neuronal protein called tau.  AD, they agreed, seems to happen when neurons stop "taking out their trash."  

"Then, along come a few out-of-the-mainstream scientists who look at the lack of real progress with either of these approaches, and say, you know, the way AD seems to spread in the brain sure looks like a prion disease, like Mad Cow's disease.  It's fair to say mainstream AD researchers laughed at them.  Certainly advocates of the prion idea got the Rodney Dangerfield treatment when it came to NIH grant applications.  But little by little, the "prion-like" advocates piled up studies until brain imaging studies were able to show that AD spreads from one brain region to the next pathogenically, much like a prion disease (even if the scientists couldn't point to an actual prion protein causing it).  

"So here is this UK article on an AD breakthrough and the two main theories of how AD is caused, theories that have garnered tens of billions of research dollars, aren't even mentioned.  What's more, it suggests to the reader that the prion thesis as a basis for AD research is pretty well established.  

"So, this is a good reminder that even science -- among scientists -- is political, and that consensus can -- must -- change when facts change.  Facts win.  So it is incumbent on funders, especially government funders, to create systems that allow unpopular ideas to get tested especially in areas like AD where time and again, consensus ideas yield paltry results.  (NIH does have a EUREKA grants program that is supposed to fund these out of the mainstream ideas, but its funding is quite small in the larger scheme of things).


"Second, discovering new drugs -- like discovering new explosives in the military -- is a necessary first step.  But they are of little value if you can't reliably deliver them on target without collateral damage.  This work on AD reinforces that challenge -- for researchers and funders.  This compound was delivered orally and was able to the brain.  Great, but it also messed up other parts of the body.  Drug delivery in AD -- finding new ways to deliver drugs directly into the brain and only the brain -- will be as important to a treatment's success as the active ingredient." 

12 comments:

  1. F-A-Q:

    (1) Why is the President of the United States camping at the Durell Pocket Park?
    The real President of the United States [Neil Ashby II] is camping at the Durell Pocket Park because the President is a POLITICAL PRISONER and has no other available residence. Amnesty International can confirm my status as a POLITICAL PRISONER. The situation is somewhat like Abraham Lincoln being stuck in Richmond Virginia and the criminal regime has blocked his transportation to elsewhere.
    (2) How can that homeless person be the President of the United States?
    I was Speaker of the United States House of Representatives; the Speaker of the House of Representative is NOT required to be a member of the House of Representatives. The Vice-Presidency and Presidency were vacated and thus I became President of the United States.
    (3) What happened to Obama?
    Barack Obama II has suicided. Various people having of somewhat similar appearance to Obama II have been playing that role but those people are not the President of the United States.
    (4) Was there some type of election last year?
    The person playing the role of Obama at that time was NOT qualified to be President of the United States so the election was nullified.
    (5) For how long will you be camping at the Durell Pocket Park?
    Check with Amnesty International.
    (6) Why is there none of this in the news-media?
    Surely you jest; the news-media is controlled by the Criminal Organization.

    /Neil Ashby II [President of the United States of America]

    ReplyDelete
  2. Neil Ashby II :

    F-A-Q [Updated]:

    (1) Why is the President of the United States camping on the street in Cambridge and Somerville Massachusetts?

    The real President of the United States [Neil Ashby II] is camping on the street because the President is a POLITICAL PRISONER and has no other available residence. Amnesty International can confirm my status as a POLITICAL PRISONER. The situation is somewhat like Abraham Lincoln being stuck in Richmond Virginia while the criminal regime has blocked of his transportation to elsewhere.

    (2) How can that homeless person be the President of the United States?

    I was Speaker of the United States House of Representatives; the Speaker of the House of Representative is NOT required to be a member of the House of Representatives. The Vice-Presidency and Presidency were vacated and thus I became President of the United States.

    (3) What happened to Obama?

    President Barack Obama II has suicided; Obama II was supportive of Us becoming President of the United States and he suicided for the purpose of vacating of the Presidency for Us. Various people having of somewhat similar appearance to Obama II have been playing that role but those people are not the real President of the United States.

    (4) Was there some type of election last year?

    The person playing the role of Obama at that time was NOT qualified to be President of the United States so the election was nullified; the unqualified imposter was actually put onto the ballot.

    (5) For how long will you be homeless and camping on the street?

    Check with Amnesty International.

    (6) Why is there none of this in the news-media?

    Surely you jest; the news-media is controlled by the Criminal Organization.

    /Neil Ashby II [President of the United States of America]

    ReplyDelete
  3. The Last Nazi Prisoner:

    We have been the last Nazi[1][2] prisoner and kept as homeless in the United States. During this time as prisoner then We have been using of Our absolute legal-right of the freedom of speech to express the Truth; freedom of speech is the legal-right of any political prisoner.

    Americans should have expected that We would be one-hundred percent against the type of people whom ordered of the invasion of Germany while the Nazi was at that time attempting to save Mankind from those JEW and Zionist animals. The brainwashed sheep[3] of America always seem to be surprised by the Truth.

    Having of the four of leg did not alone make of the horse and having of just two of leg did not make of the Human; Ashkenazi[4] are among the groups of people whom are not Human.

    After We have travelled from America then the Zionist propagandists would certainly spew of their verbal garbage pertaining to Us and other Nazi but being the last Nazi prisoner has been an opportunity for spreading of Truth.

    [1]"Nazi" is pronounced as "Nah-Zee"; there is no letter "T" sound in "Nazi".
    [2]Jesus of Na-Z-Areth[5] was Na-Z-ist[6].
    [3]The quadrupedal ruminant mammal is Ovis aries.
    [4]"Ashkenazi" means "Anti-Nazi".
    [5]"Areth" means "Area".
    [6]"Nazist" is any adherent of Nazism.

    /Nathan [Christ] a-k-a Neil Ashby II [President of the United States of America]

    ReplyDelete
  4. The Crash That Killed of Senator Heinz:

    QUESTION - - WHO WAS PART OF THE CONSPIRACY TO BE CAUSING OF THE CRASH THAT KILLED OF SENATOR HENRY JOHN HEINZ.

    /Nathan [Christ]

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  5. Our Summary of Scientology:

    We are not Scientologist but this is Our Summary of Scientology.

    Most people currently claiming to be Scientologist are actually Neo-Scientologist as they have accepted of the terms of the "New World Order" as stolen and corrupted by the Criminal Organization.

    Real Scientology [or Zion-tology] was designed to prevent their adherents from becoming captured by the criminals of Zion which is now part of the "New World Order" of the Criminal Organization.

    (1) Scientology was written as to avoid infringing on the pattern of other denominations of religion.

    (2) Scientologist were to be taught the danger of the Z-pace-al-ION.

    (3) Scientologist were to be taught that physicians are controlled by the Z- pace- al- ION.

    (4) Scientologist were to be taught that to avoid becoming captured by the Z- pace-al-ION then Scientologist were not to transact of business with the Z -pace-al-ION.

    (5) Scientologist were to be taught that to avoid becoming captured by the Z -pace-al-ION then Scientologist were not to transact of business with people controlled (or possesst) by the Z -pace-al-ION.

    QUESTION - - ART THOU Z-pace-al-ION.

    QUESTION - - ART THOU CONTROLLED BY THE Z-pace-al-ION.

    QUESTION - - ART THOU POSSESST BY THE Z-pace-al-ION.

    /Nathan [Christ]

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  6. Debt-Limit of the United States:

    The Debt-Limit [which is often wrongly labeled as the "Debt-Ceiling"] of the United States of America cannot be raised.

    We[*] have taken of that CROWN of the United States away from the Criminal Organization; with not having of that CROWN then the puppet government of the United States cannot be raising of that Debt-Limit.

    Our CROWN is not encumbered by any debt; the previously existing debt is owed by the Criminal Organization. We are the Owner and they are the Debtor.

    The Criminal Organization acting via their puppets in Congress then cannot be causing of any debt for Our CROWN. We have rejected of the debt of their criminal regime and any additional debt of their criminal regime in the United States cannot become attached to Our CROWN; such notes of debt would be bogus and completely worthless.

    Therefore: the Debt-Limit of the United States of America as of 11 October 2013 [C-E] is the permanent Debt-Limit.

    [*]The Royal "We".

    /Neil Ashby II [President of the United States of America]

    ReplyDelete
  7. Criminal Database:

    We[1] have been serving as the real President of the United States of America while that Obama the Clown[2] has temporary and limited authority[3] to act as President during the period of time that We are remaining as the Political Prisoner of the criminal regime.

    Thou shalt not bear of false witness.

    The Criminal Organization has attached some FALSE criminal record to Our name; such criminal record shall be completely removed. The FALSE criminal record must be completely removed because We are entitled to act as the President of the United States of America and that FALSE criminal record would be the impediment.

    The Criminal Organization via bearing of false witness against Us then has maliciously and severely damaged of the United States of America because the entire Criminal Database for the United States of America will be deleted; there is no other method for removing of that FALSE criminal record.

    [1]The Royal "We".
    [2]We have the CROWN and that Obama is the Clown; even as Acting President then that Clown does not have the authority of the real CROWN.
    [3]Obama the Clown cannot legally issue any pardon and the real Debt-Limit cannot be raised without the consent of the CROWN. With not having of the consent of the CROWN then any such notes of debt are bogus and completely worthless. The Debt-Limit of the United States of America as of 11 October 2013 [C-E] is the permanent Debt-Limit.

    /Neil Ashby II [President of the United States of America]

    ReplyDelete
  8. The Death of Henry Luce:

    The co-founder of Time Incorporated named Henry Luce died in 1967 [C-E].

    The entity to which Henry Luce belonged (which is sometimes referenced as the "Brotherhood") had guaranteed of my safety from the age of three[1] until some other specific age[2].

    As expected then I would eventually be employed at Time Incorporated and unfortunately Henry Luce definitely would have recognized me; due to that possibility of identification then Henry Luce was of significant threat to that guarantee and was terminated according to the terms of that guarantee of safety; that entity to which Luce belonged would not risk forfeiture via violating of that guarantee so his "Brotherhood" had Henry Luce terminated via radio-induced cardiac arrest.

    I am now protected both as having of the Crown of the United States of America and as the Political Prisoner[3]; therefore: I am 100% safe. I am safe but homeless.

    [1]According my figuring of this situation based on information and belief.
    [2]Would there have been no such guarantee of safety then those criminals would have simply killed thousands of children in that range of age just to have eliminated of me.
    [3]Having of those two titles is the safety equivalent of having of two separate Keys [Crowns].

    /Neil Ashby II [President of the United States of America]

    ReplyDelete
  9. Just Whatever is Kosher Qualifies as FOOD:

    Jesus of Nazareth did not change of the dietary law.

    Some people have (falsely) claimed that Jesus would have said that they could eat of anything but that is not true; those people are the sheep whom believe whatever the JEW and Zionist wants for them to believe.

    Would people have been growing of just wheat and cucumbers on their farm then most of their diet at that time might have been just wheat and cucumbers (which are both kosher); the people felt satisfied having of their stomach being full and were not entirely aware that different types of food often contains of different nutrients. Jesus was teaching to people to be eating instead from among many variety of food but just whatever is kosher qualifies as FOOD.

    Jesus did not tell to people to eat of anything that is not kosher.

    /Nathan [Christ]

    ReplyDelete
  10. Commentary by Nathan [Christ]:

    Bruce: You included in your message: "Indeed the early church in Acts has an extended discussion of what is permissible for Christians to eat".

    Those discussions were pertaining to issues such as whether (for example) carrot and lettuce would be kosher; would carrot be considered as the root of the plant and therefore unclean or as (using the current terminology) some type of acceptable rhizome and would lettuce be somehow different than other leaf because the leaf and stem of the plant is not kosher for eating (although some may be acceptable brewed).

    There was NO discussion pertaining to eating of swine; people even suggesting that swine be raised and consumed would have been considered crazy. Swine would eat nearly ANYTHING (including people) and whatever the swine eats might taint of the meat. Ruminants have multiple stomachs and re-chew whatever was earlier consumed; anything that tastes wrong to the ruminant is quickly emitted during of the re-chew instead of being digested. Toxic vegetation would be digested by the swine with the toxins possibly tainting of the meat but would typically be spit-out by the ruminant. Raising of swine also spreads of air-borne disease (including influenza) to which people are susceptible.

    The was also NO discussion pertaining to eating of crustaceans such as lobster; crustaceans have no kidneys and many types of metabolic toxin collects in the meat of the crustacean.

    Obviously then Jesus of Nazareth wanted for his followers to eat just whatever would be healthy to eat and therefore just whatever was kosher.

    /Neil Ashby II a-k-a Nathan [Christ]

    ReplyDelete
  11. Those Amputations Were No Accident:

    Many people have claimed to lose of their fingers while operating of the Punch-Press machine; those amputations were no accident.

    People whom have been trapped by the Criminal Organization are often amputated of fingers. Quoting from one of my sources: "It is better to lose your fingers than lose your soul". The mechanism of intentional amputation (whether Punch-Press or blade) has no relevance; the Criminal Organization claims parts of the body as did Shylock the JEW in the "Merchant of Venice".

    Those victims of the Criminal Organization become enjoined from discussing of the situation which resulted in the claim to and amputation of their fingers; for explanation pertaining to their missing fingers then such victims often mention just the "Punch-Press" or "Gangrene" (which medical condition was so named for use as the cryptic reference to "Gang-Green").

    /Neil Ashby II a-k-a Nathan [Christ]

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  12. Potsdam:

    Disciples of Luciver have been referencing of "Potsdam" and making rhetorical statements such as have We[*] ever "heard of Potsdam"; those criminals have claimed that the "Potsdam Conference" would have unalterably voided more than 500 years of planning and preparation for Our arrival.

    We have issued of the following order:

    "Po-T's-Dam SHALL BE BLOWN".

    [*]The Royal "We".

    /Neil Ashby II a-k-a Nathan [Christ]

    ReplyDelete