tag:blogger.com,1999:blog-58772210188008303622024-03-12T22:38:19.729-04:00Cure Strategy (formerly, Serious Medicine Strategy)A cure is better, and less expensive, than care. It's cheaper to beat than to treat. James P. Pinkertonhttp://www.blogger.com/profile/06914344842339708576noreply@blogger.comBlogger452125tag:blogger.com,1999:blog-5877221018800830362.post-5053571712340467292014-11-05T17:57:00.004-05:002014-11-05T17:57:24.582-05:00House Energy and Commerce Committee Chair Fred Upton (R-Mich.) on Cure Strategy<div dir="ltr" style="text-align: left;" trbidi="on">
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<span class="s1"><b><a href="http://www.nationaljournal.com/library/199771">Upton statement on committee priorities for the 114th Congress</a></b></span></div>
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<span class="s1">ISSUED BY</span></div>
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<span class="s1">Fred Upton</span></div>
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<span class="s1">November 5, 2014</span></div>
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<span class="s2">Earlier this year my Democratic colleague Diana DeGette joined me in launching the <a href="http://links.govdelivery.com/track?type=click&enid=ZWFzPTEmbWFpbGluZ2lkPTIwMTQxMTA1LjM3ODQxMjUxJm1lc3NhZ2VpZD1NREItUFJELUJVTC0yMDE0MTEwNS4zNzg0MTI1MSZkYXRhYmFzZWlkPTEwMDEmc2VyaWFsPTE2OTg2MDA1JmVtYWlsaWQ9bmljaG9sYXMuY3VscEBtYWlsLmhvdXNlLmdvdiZ1c2VyaWQ9bmljaG9sYXMuY3VscEBtYWlsLmhvdXNlLmdvdiZmbD0mZXh0cmE9TXVsdGl2YXJpYXRlSWQ9JiYm&&&101&&&http://energycommerce.house.gov/cures"><span class="s3">21st Century Cures</span></a></span><span class="s1"> initiative with the goal of accelerating the pace of new cures and treatments. We have heard from patients, researchers, care givers, and innovators for the past several months about the tremendous opportunities we have in the United States to find treatments for the thousands of diseases without them and close the gap between the science of cures and how we regulate them. In the coming weeks we will continue to advance this initiative and work with our colleagues in Congress and the administration to deliver hope to patients and loved ones all across the country. </span></div>
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James P. Pinkertonhttp://www.blogger.com/profile/06914344842339708576noreply@blogger.com16tag:blogger.com,1999:blog-5877221018800830362.post-65914840146605921832014-10-28T14:12:00.003-04:002014-10-28T14:12:35.897-04:00Today is the Centennial of the birth of Dr. Jonas Salk--it's nice to see Google taking note <div dir="ltr" style="text-align: left;" trbidi="on">
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James P. Pinkertonhttp://www.blogger.com/profile/06914344842339708576noreply@blogger.com11tag:blogger.com,1999:blog-5877221018800830362.post-68304157380527965972014-05-09T20:22:00.002-04:002014-05-09T20:22:11.981-04:00Fred Upton Leads a Cure Strategy for the 21st Century <div dir="ltr" style="text-align: left;" trbidi="on">
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My piece for <a href="http://www.breitbart.com/Big-Government/2014/05/09/Hope-Comes-to-RHOB-2123">Breitbart News</a>. </div>
James P. Pinkertonhttp://www.blogger.com/profile/06914344842339708576noreply@blogger.com45tag:blogger.com,1999:blog-5877221018800830362.post-70720155521531593422014-03-24T11:09:00.002-04:002014-03-24T11:11:14.240-04:00The Same Issues as the AIDS Crisis, three decades later <div dir="ltr" style="text-align: left;" trbidi="on">
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<span class="s1">This article appears on the front page of the hard-copy of <a href="http://www.washingtonpost.com/national/health-science/crowdsourcing-medical-decisions-ethicists-worry-josh-hardy-case-may-set-bad-precedent/2014/03/23/f8591446-ab81-11e3-adbc-888c8010c799_story.html?hpid=z5">The Washington Post</a> today. </span></div>
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Three decades ago, it was AIDS. Now, it's a myriad of illnesses. And once again, individuals, and their families, are fighting off deadly diseases. And once again, the bureaucracy is on the other side. </div>
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And curiously, the Post seems to be on the side of the bureaucrats. That is, the side of "regular order," the side of trusting the system to do the right thing. Very curious. </div>
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What we really need is a wide-open system of compassionate use, plus maximum experimentation. That's how problems get solved the fastest. </div>
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<span class="s1">And while it would be nice if our leaders, including within the bureaucracy, had such vision, it's nice that somebody, at least, has it. As the AIDS activists proved, vision from the bottom up can get the job done--or at least push the ball forward. </span></div>
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James P. Pinkertonhttp://www.blogger.com/profile/06914344842339708576noreply@blogger.com626tag:blogger.com,1999:blog-5877221018800830362.post-29705965589620271492014-01-04T15:16:00.003-05:002014-01-04T15:52:18.446-05:00"Infectious Causation of Disease: An Evolutionary Perspective" <div dir="ltr" style="text-align: left;" trbidi="on">
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<span style="background-color: white; color: #404040; font-family: Roboto, arial, sans-serif; font-size: 13px; line-height: 18px;"><a href="https://plus.google.com/111721478237564316228/posts/JPN46hepH7s">Fascinating, important, and provocative piece</a> by Cochran, Ewald, and Cochran, first published in 2000, in <i>Perspectives in Biology and Medicine</i>.</span><br />
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James P. Pinkertonhttp://www.blogger.com/profile/06914344842339708576noreply@blogger.com118tag:blogger.com,1999:blog-5877221018800830362.post-86015934743883183122013-12-31T07:35:00.001-05:002013-12-31T07:35:13.432-05:00Lloyd Green, Writing in The Daily Beast, Takes Note of the Cure Strategy <div dir="ltr" style="text-align: left;" trbidi="on">
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<a href="http://www.thedailybeast.com/articles/2013/12/31/want-hope-in-2014-forget-politics-focus-on-energy-and-medicine.html">This article,</a> full of hope for transformative technology, quotes Jim Pinkerton herein:<br />
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<span style="font-family: inherit;"><b><span style="line-height: 30px;">Yes, all that will make for great theater in the run-up to November’s congressional elections, and fortunately for the Republicans, health insurance’s implosion is happening on Obama’s watch. But I’m talking about medicine, medical research, and cures. As Jim Pinkerton, a former White House domestic policy adviser to Presidents Reagan and Bush 41, </span><a href="http://seriousmedicinestrategy.blogspot.com/" sl-processed="1" style="-webkit-transition: color 0.2s ease-in-out; box-sizing: border-box; color: #6c899d; cursor: pointer; display: inline; line-height: 30px; outline: 0px; text-decoration: none; transition: color 0.2s ease-in-out;" target="_blank">likes to say</a><span style="line-height: 30px;">, “A cure is better than care. It’s cheaper to beat than to treat.”</span></b></span></div>
James P. Pinkertonhttp://www.blogger.com/profile/06914344842339708576noreply@blogger.com18tag:blogger.com,1999:blog-5877221018800830362.post-57375893204441619752013-12-29T06:54:00.004-05:002013-12-29T07:10:31.928-05:00Fighting Killer Diseases vs. Fighting Gender Disorientation. Connecticut Makes Its Choice. <div dir="ltr" style="text-align: left;" trbidi="on">
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<span style="font-family: inherit;"><span style="background-color: white; color: #333333; line-height: 17.98611068725586px;">Reuters reports that people are dying of new viruses in</span><a href="http://www.reuters.com/article/2013/12/27/us-mers-saudi-idUSBRE9BQ04M20131227" style="line-height: 17.98611068725586px;"> Saudi Arabia</a><span style="background-color: white; color: #333333; line-height: 17.98611068725586px;"> and </span><a href="http://www.reuters.com/article/2013/12/26/us-hongkong-birdflu-idUSBRE9BP06P20131226" style="line-height: 17.98611068725586px;">Hong Kong</a><span style="background-color: white; color: #333333; line-height: 17.98611068725586px;">. Which is to say, the next round of</span><a href="http://contagionmovie.warnerbros.com/dvd/" style="line-height: 17.98611068725586px;"> contagion</a>, this time in the real world, <span style="background-color: white; color: #333333; line-height: 17.98611068725586px;">could be</span><span style="background-color: white; color: #333333; line-height: 17.98611068725586px;"> just an airplane-ride away. Meanwhile, the state of Connecticut is pushing forward on a different cause--it is mandating that health insurers pay for gender-reassignment. </span><i style="color: #333333; line-height: 17.98611068725586px;"><a href="http://www.courant.com/news/politics/hc-gender-identity-connecticut-1227-20131226,0,1545137.story">The Hartford Courant</a></i><span style="background-color: white; color: #333333; line-height: 17.98611068725586px;"> reports: </span></span><br />
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<span style="background-color: white; color: #292727; line-height: 22.5px;"><b><span style="font-family: inherit;">The Connecticut Insurance Department is directing all health insurance companies operating in the state to provide coverage of mental health counseling, hormone therapy, surgery and other treatments related to a patient's gender transition.</span></b></span><br />
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<span style="font-family: inherit;">Such mandates could have something to do with higher "healthcare" costs. That is, if governments are continue to pile more mandates on the insurance system, of course costs will go up. So much for "bending the curve." People should be free to choose their own destiny, but it's not so obvious that the rest of us should pay for it. </span><br />
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<span style="font-family: inherit;">At the very minimum, we should be honest enough to admit that restraining the growth of healthcare costs if not going to be possible if the government continues to unconstrain healthcare costs. </span><br />
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<span style="font-family: inherit;">Meanwhile, people are dying. </span></div>
James P. Pinkertonhttp://www.blogger.com/profile/06914344842339708576noreply@blogger.com11tag:blogger.com,1999:blog-5877221018800830362.post-66323832486247986142013-12-19T21:59:00.001-05:002013-12-19T21:59:12.797-05:00Peggy Noonan on the Cure Strategy <div dir="ltr" style="text-align: left;" trbidi="on">
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Peggy Noonan, writing in <a href="http://online.wsj.com/news/articles/SB10001424052702304367204579268591272440548"><i>The Wall Street Journal</i></a>: </div>
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<b>There are also the words this year that were most conspicuous by their absence. They're the words we don't use when we talk about health care. Actually we don't talk much about health care, we talk about health insurance. Fox News's Jim Pinkerton says the absent words in the ongoing debate are "medicine," "research" and "cure." Do you want to make a dent in future health-care costs? Cure Alzheimers. That's where the cost will be as the health of the baby boomers falters. Insurance isn't the key. It was never the key. It's a product. Cure and care are the words of the future.</b></div>
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James P. Pinkertonhttp://www.blogger.com/profile/06914344842339708576noreply@blogger.com0tag:blogger.com,1999:blog-5877221018800830362.post-23151667270031085482013-12-02T09:54:00.001-05:002013-12-02T09:56:45.969-05:00"New Computer-Designed 'Drug" Prevents AIDS From Replicating" <div dir="ltr" style="text-align: left;" trbidi="on">
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<a href="http://io9.com/new-computer-designed-drug-prevents-aids-from-replica-1473572265"><b>New Computer-Designed 'Drug' Prevents AIDS From Replicating</b></a></div>
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Is this headline true? false? If it's even a little bit true, then we can see the prospect of a whole new kind of medicine, and whole new industries. And, of course, a lot of hope for a lot of people.<br />
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It certainly seems like a prospect that should entice the interest of DC policymakers.<br />
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James P. Pinkertonhttp://www.blogger.com/profile/06914344842339708576noreply@blogger.com0tag:blogger.com,1999:blog-5877221018800830362.post-46750779234431798222013-11-26T21:24:00.001-05:002013-11-26T21:24:12.009-05:00We need more antibiotics--now. <div dir="ltr" style="text-align: left;" trbidi="on">
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In the words of <i>The Week's</i><a href="http://theweek.com/article/index/253397/why-the-post-antibiotic-world-is-the-real-life-version-of-the-zombie-apocalypse"> John Aziz</a>: </div>
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"If the problem continues to grow, the U.S. and other countries will have to invest a whole lot more in antimicrobial technologies, or create incentives for Big Pharma to do so. Like the zombie apocalypse, the post-antibiotic world would not be a pretty place to live in."</div>
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It sure seems that next-gen antibiotics are not only a public health necessity, but also a good business--creating lifesaving products not only for Americans, but also to be sold to the world. It's also hard to see how we could "bend the curve" on healthcare costs if there's a big epidemic. </div>
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James P. Pinkertonhttp://www.blogger.com/profile/06914344842339708576noreply@blogger.com0tag:blogger.com,1999:blog-5877221018800830362.post-53357518327459793112013-11-16T13:49:00.005-05:002013-11-16T14:42:05.893-05:00Peter Huber's "The Cure in the Code: How 20th Century Law is Undermining 21st Century Medicine" <div dir="ltr" style="text-align: left;" trbidi="on">
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Peter Huber's<i> </i><a href="http://www.amazon.com/The-Cure-Code-Undermining-Medicine/dp/0465050689/ref=sr_1_1?ie=UTF8&qid=1384627882&sr=8-1&keywords=peter+huber">new book</a>, <i>The Cure in the Code: How 20th Century Law is Undermining 21st Century Medicine </i>is both provocative and inspiring. Once again, the Manhattan Institute scholar shows his extraordinary grasp of both technological and legal issues. </div>
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Huber is certainly correct in arguing that a) laws concerning intellectual property and b) the regulatory procedures of the FDA and the federal government in general are inhibiting medical progress--at least within the current parameters of how medical progress is achieved. More specifically, the status quo is impeding medical cures--and it's great to see Huber using the word "cure" in the title. </div>
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Why? Because only the idea of cures fully animates political activity. In politics, goals drive process. By contrast, process by itself is kind of a snooze to politicians, and to the public. In 1962, John F. Kennedy didn't say that he wanted to increase NASA's budget by 84 percent--he said he wanted the US to go to the moon by the end of the decade. </div>
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It was that galvanic message that punched through. It was that goal that drove not only NASA's budget, but also, of course, America's success in putting a man on the moon. </div>
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Indeed, it's a good thing that Huber sets forth the goal of cures, because only that big and worthy goal will overcome the inertial, even hostile, forces that block progress. </div>
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In particular, Huber identifies two recent US Supreme Court cases, <i><a href="http://www.supremecourt.gov/opinions/12pdf/12-398_1b7d.pdf">Association for Molecular Pathology v. Myriad Genetics</a></i> and <i><a href="http://www.supremecourt.gov/opinions/11pdf/10-1150.pdf">Mayo Collaborative Services v. Prometheus Laboratories</a>, </i>which have--incorrectly in Huber's view--dramatically limited the right of private companies to create and defend IP claims. If companies can't create monetizable IP, Huber reasons, they won't go to the expense of creating it at all. </div>
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As he puts it, "Well-crafted property rights promote the broad and economically efficient distribution of know-how." </div>
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It's a strong argument, but there's also a strong counter-argument. </div>
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In fact, there's a huge constituency in favor of "open source" medical research, as part of the larger <a href="http://en.wikipedia.org/wiki/Open_source">open-source movement</a>. These open-sourcers argue just the opposite of Huber--they argue that the public benefits of open exchange of information far outweigh the benefits of privatizing medical discoveries. Indeed, they would further dispute the very idea that a naturally occurring entity ought to be patented at all. </div>
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We might recall that the open-sourcers seem able to count a majority of the Supreme Court. In other words, those who vehemently disagree with Huber seem to have the upper hand right now. </div>
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In addition to arguing for a more "robust" IP regime, Huber argues that researchers and companies will need to be able to create data consortia, so that the benefits of Big Data can be fully felt in the medical field. As Huber puts it, "For well over a century, competing companies have been pooling their patents and interconnecting their telegraph, phone, and data networks, online reservation systems, and countless other information conduits and repositories." </div>
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Huber is right, of course, but every one of these arrangements was controversial. That's why politicians and regulators had to step in to make the system work; back in 1913, for example, the <a href="http://en.wikipedia.org/wiki/Kingsbury_Commitment">Kingsbury Commitment</a>, for example, encouraged AT&T to create a near-monopoly over US telephone service, and as that monopoly became increasingly controversial, in 1984 it was reversed by the AT&T breakup. </div>
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So, three decades later, is this the time to bring in new kinds of data consortia? Is this the time to overcome various rules--most obviously, <a href="http://www.hhs.gov/ocr/privacy/hipaa/understanding/summary/">HIPAA</a>--that inhibit, even prohibit, massive data sharing? Perhaps the correct answer is "yes," but if so, it will take a lot of political and legal muscle to overcome the opposition. </div>
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In fact, it will probably require some updated framework for medical research, one that takes into account a) the imperative of scientific progress, b) the imperative of making sure that the benefits are fairly shared across society, and c) the need to protect privacy. No doubt there's a way to achieve all three criteria, but the political coalition that's needed does not yet exist. </div>
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And as noted in my earlier post on <a href="http://seriousmedicinestrategy.blogspot.com/2013/11/md-andersons-cancer-moon-shot.html">M.D. Anderson's "moon shot" cancer initiative</a>, the key to developing political energy to move forward is found in the establishing of big and worthy goals--goals such as curing cancer. </div>
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If those goals are established, and supported by the public, then just about anything is possible. </div>
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But if the goals are fuzzy, then the status quo survives. </div>
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James P. Pinkertonhttp://www.blogger.com/profile/06914344842339708576noreply@blogger.com2tag:blogger.com,1999:blog-5877221018800830362.post-66366116590294937472013-11-16T13:48:00.001-05:002013-11-16T14:49:13.527-05:00MD Anderson's Cancer "Moon Shot"<div dir="ltr" style="text-align: left;" trbidi="on">
Earlier today I was clicking around at <i><a href="http://www.businessinsider.com/warburg-pincus-private-equity-firm-2013-11">The Business Insider</a></i>, and saw this ad, from the <a href="http://www.mdanderson.org/?cmpid=Google_BL%7cX%7cMDA%20Cancer%20Center%7cBrand%7cExact_BL%7cMDA%20Cancer%20Center%20-%20Brand%7cBrand%20Terms_m%20d%20anderson_ppc&gclid=CM3OtOL26boCFUzxOgoda1UATw&gclid=CM3OtOL26boCFUzxOgoda1UATw">M.D. Anderson Cancer Clinic</a> in Houston. It puts forth a very ambitious vision, summoning up the memory of <a href="http://er.jsc.nasa.gov/seh/ricetalk.htm">John F. Kennedy's "moon shot" speech of September 12, 1962</a>--delivered, interestingly enough, in Houston. <br />
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Here're some glimpses of the ad:<br />
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<a href="http://1.bp.blogspot.com/-1v58yRkxi28/Uoe5f8mj09I/AAAAAAAAICU/8AUasjBLDJw/s1600/MD+1.png" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="181" src="http://1.bp.blogspot.com/-1v58yRkxi28/Uoe5f8mj09I/AAAAAAAAICU/8AUasjBLDJw/s400/MD+1.png" width="400" /></a></div>
Indeed, it's nice to see an entity, Anderson, that sets ambitious goals...<br />
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<a href="http://2.bp.blogspot.com/-2JYc2fqg2GA/Uoe6QY0yOeI/AAAAAAAAICk/DYCd_2pOD7g/s1600/MD+3.png" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="178" src="http://2.bp.blogspot.com/-2JYc2fqg2GA/Uoe6QY0yOeI/AAAAAAAAICk/DYCd_2pOD7g/s400/MD+3.png" width="400" /></a></div>
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... ending cancer: </div>
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<a href="http://1.bp.blogspot.com/-OUCHhVKnm0M/Uoe6hGEhXEI/AAAAAAAAICs/vwyxnf1N37g/s1600/MD+4.png" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="178" src="http://1.bp.blogspot.com/-OUCHhVKnm0M/Uoe6hGEhXEI/AAAAAAAAICs/vwyxnf1N37g/s400/MD+4.png" width="400" /></a></div>
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This all heartening, of course. </div>
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Curious as to this program, I went to YouTube, and discovered that this spot seems to be derived from <a href="http://www.youtube.com/watch?v=7Nnzt_J31Jo">a longer spot released by M.D Anderson</a> back in September 2012. It also has a strong message: </div>
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<a href="http://4.bp.blogspot.com/-xzYgl53ccUY/Uoe7dCgHFtI/AAAAAAAAIC4/AAzEkxQAioo/s1600/Time+is+Now.png" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="291" src="http://4.bp.blogspot.com/-xzYgl53ccUY/Uoe7dCgHFtI/AAAAAAAAIC4/AAzEkxQAioo/s400/Time+is+Now.png" width="400" /></a></div>
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And it, too, invokes JFK: </div>
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And the space program:</div>
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<a href="http://4.bp.blogspot.com/-WV4OExv2yoc/Uoe8bfflBnI/AAAAAAAAIDQ/2Ap0vgDh834/s1600/Beyond.png" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="286" src="http://4.bp.blogspot.com/-WV4OExv2yoc/Uoe8bfflBnI/AAAAAAAAIDQ/2Ap0vgDh834/s400/Beyond.png" width="400" /></a></div>
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It even details the cancers being targeted: </div>
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<a href="http://2.bp.blogspot.com/-UWA3bR3j_h0/Uoe77TB8yGI/AAAAAAAAIDI/2mk1ecF3800/s1600/%231.png" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="288" src="http://2.bp.blogspot.com/-UWA3bR3j_h0/Uoe77TB8yGI/AAAAAAAAIDI/2mk1ecF3800/s400/%231.png" width="400" /></a></div>
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Indeed, Anderson even seems eager to eliminate its "business model"--that is, treating cancer. </div>
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This is all great, but I couldn't help notice one little discouraging item--more than a year after its release, the video had less than 18,000 views. </div>
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That's not a crippling concern, if the right 18,000 people are watching. Or, of course, if Anderson's end cancer message is otherwise punching through. But so far, at least, it seems that it isn't.</div>
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That's not Anderson's fault; it's got all the right ideas, and it's obviously trying hard to get its message out. The problem--okay, let's be positive here, and call it an "opportunity not yet seized"--is that political leaders have not yet grasped the idea that curing disease is a political winner. </div>
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Let's hope that changes. </div>
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James P. Pinkertonhttp://www.blogger.com/profile/06914344842339708576noreply@blogger.com0tag:blogger.com,1999:blog-5877221018800830362.post-81694152842192060972013-11-03T06:57:00.000-05:002013-11-13T14:17:17.513-05:00Of Pindar and the Politics of Longevity: Larry Page, Meet the Hayflick Limit, Henrietta Lacks and the Ironic Secret of Cancer <div dir="ltr" style="text-align: left;" trbidi="on">
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Google co-founder and CEO Larry Page is super-smart and super-rich. Now, he wants to end aging as we know it. And all of us who are aging should naturally wish him well. But as Lt. Columbo would say on the 70s TV show, <a href="http://www.youtube.com/watch?v=biW9BbWJtQU">“There’s just one more thing.”</a><br />
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<span class="s1">That “one thing” is context. Specifically, political context. In the abstract, putting an end to aging may be a scientific mission. But in the real world—and even megabillionaire tech titans inhabit the real world—a massive new medical-scientific effort will end up being political. That’s why it’s so important for Page’s effort to be anchored in public support. </span></div>
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<span class="s1">Without a new doubt, Page’s new venture, Calico—an ironically understated acrostic of “California Life Company"—is aiming big. As Page said in a September 18 <a href="http://googlepress.blogspot.com/2013/09/calico-announcement.html">Google press release</a>,</span></div>
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<span class="s1"><b>“Illness and aging affect all our families. With some longer term, moonshot thinking around healthcare and biotechnology, I believe we can improve millions of lives.” </b></span></div>
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<span class="s1">We certainly admire moonshot-type thinking. Nobody rallied the nation to a great goal better than John F. Kennedy. Thanks to the firm support of the American people, the space program reached its goal. So here we are reminded that the Apollo mission was, in fact, a public program. It endures today as one of the great triumphs of the United States—all Americans can take pride in its success. </span></div>
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<span class="s1">Back to the here and now, Calico has enlisted Arthur D. Levinson, Chairman and former CEO of Genentech, to be an investor-CEO of the new venture. Genentech under Levinson developed landmark drugs to attack certain kinds of breast, colon, and lung cancers. The Google press release included poignant words from Apple CEO Tim Cook:</span></div>
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<span class="s1">“For too many of our friends and family, life has been cut short or the quality of their life is too often lacking. [Levinson] is one of the crazy ones who thinks it doesn’t have to be this way. There is no one better suited to lead this mission and I am excited to see the results.”</span></div>
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<span class="s1">Cooks’s predecessor at Apple, of course, was Steve Jobs, who died of cancer at 56. So there’s every reason to hope that Calico succeeds. Indeed, if it does succeed, one can imagine a new longevity business that would make even mighty Google look small. </span></div>
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<span class="s1">Given Levinson’s background, and the lingering presence of Jobs’ example -- life cut short -- you’d think cancer would be a big concern of a life-extending effort. According to the <a href="http://www.cancer.org/research/cancerfactsstatistics/cancerfactsfigures2013/index">American Cancer Society</a>, nearly 1.7 million Americans will be diagnosed with cancer in 2013, and more than 580,000 will die of it. </span></div>
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<span class="s1">Yet curiously, in a recent <a href="http://content.time.com/time/magazine/article/0,9171,2152422,00.html">Time interview</a>—the magazine’s cover story asked, “Can Google Solve Death?”—Page seemed to downplay cancer’s importance. Cancer, Page seemed to muse, as bad as it is, was a sideshow on the road to longevity:</span></div>
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<span class="s1"><b>“If you solve cancer, you’d add about three years to people’s average life expectancy. We think of solving cancer as this huge thing that’ll totally change the world, but when you really take a step back ... in the aggregate, it’s not as big an advance as you might think.”</b></span></div>
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<span class="s1">Page is looking beyond cancer, or any other single disease. He is reaching, instead, for immortality. If so, then surely he is going to seek to tackle the <a href="http://en.wikipedia.org/wiki/Hayflick_limit">Hayflick Limit,</a> named after the scientist <a href="http://en.wikipedia.org/wiki/Leonard_Hayflick">Leonard Hayflick</a>. The Hayflick Limit describes the number of times a normal cell can divide. Writ large, it appears to put a time-limit on all of our lives. </span></div>
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<span class="s1">In Greek mythology, the three Moirai, or Fates, first spun the the thread of life, then measured it, and then snipped it. As the ancient poet Pindar wrote, they were “fine-armed daughters of Night…all-terrible goddesses of sky and earth.” Through the eons, the sorrow of death has a way of eliciting the greatest eloquence, haunting our imagination. In this more scientific era, the Hayflick Limit is the scientific expression of that doomed inexorability. </span></div>
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<span class="s1">Page is right that we should focus on big medical breakthroughs that might overcome the Hayflick Limit. </span></div>
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<span class="s1">Yet perhaps he is overlooking a key point when he speaks “in the aggregate” and minimizes the value of curing cancer. </span></div>
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<span class="s1">Why? Because, politically speaking, most people understand that cancer -- even with advances like Genentech medicines -- remains a seemingly random and fearsome prospect; and scientifically, in its own terrible way, cancer is immortality. </span></div>
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<span class="s1">We can see how these political and scientific strands interweave in the life of Henrietta Lacks, an African-American woman who labored in a Baltimore steel mill during World War II, raising five children. Lacks died some 62 years ago, in 1951, aged 31, the victim of a fast-growing cervical cancer. </span></div>
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<span class="s1">Her poignant story is also instructive. Though dead some 62 years, Lacks’s cancer lives on. Her tumor was rare, and, in the right cell culture, immortal. That’s the scientific value of her example, the connection between cancer and longevity. However, as described in the 2010 book, <a href="http://www.amazon.com/The-Immortal-Life-Henrietta-Lacks/dp/1400052181"><i>The Immortal Life of Henrietta Lacks</i></a>, there is a political dimension as well. Lacks’ cancer cells were extracted without her consent and farmed out to cancer researchers worldwide for decades. Decades later, with genetic screening, some of her descendants’ genetic data was published without their consent. That’s the kind of personal exploitation that breakthrough medical research must avoid at all costs. Great science benefits everyone, but it begins by respecting everyone as well. In Lacks’ case, NIH Director Francis Collins tried to right past wrongs this year, setting new rules with Lacks’ descendants governing how her cells can be used and genetic information can be released.</span></div>
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<span class="s1">Once ethical concerns about individuals’ participation in research are reconciled—and those concerns aren’t small, but they are solvable —then we can see that cancer does, in fact, offer us a window of hope on immortality. If regular cells, in becoming cancerous, can reprogram themselves to be immortal then why can’t other kinds of cells live forever, too? Like a human body? </span></div>
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<span class="s1">Scientists are making great strides in coaxing regular cells back to their primeval states, to a time before their genetic programs told them to be skin cells or liver cells, or any other cell. However, once reset, these cells remain subject to aging -- decay, degeneration, and death. By contrast, cancer causes resilient, hyper-growth tumors. It may be possible to fuse that which kills us and that which gives us life. The problem is we just don’t understand it well enough. Getting to that understanding will require great science, and leadership by scientists and politicians to build widespread support for work that may transform our lives. </span></div>
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<span class="s1">Cancer research holds a second lesson for anti-aging therapies. People with the same cancer treated the same way often have different outcomes. Some live, some don’t. Cancer therapies have to be tailored to tumor types and individuals. Like cancer, anti-aging will need to build on hundreds of millions of data points, each data point representing a person who choses to share their information. </span></div>
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<span class="s1">In law, hard cases make bad law. Not so in medicine. Unique cases shed new light on old mysteries. You never know when another Henrietta Lacks, a rare individual with a uniquely informative situation, may come along.</span></div>
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<span class="s1">As an aside, that’s why it was so disappointing to see an October 14 <a href="http://www.nytimes.com/2012/10/15/opinion/a-hospital-says-no-to-an-11000-a-month-cancer-drug.html">op-ed in <i>The New York Times</i></a>, entitled, "In Cancer Care, Cost Matters," which denounced new cancer drugs for being too expensive for the health value they offered. The three co-authors, all MD's, declare that they will boycott these new drugs. Indeed, they make it plain that they see their boycott as part of a larger effort to curb healthcare costs. As the trio asserts, "</span>The current level of spending on health care, estimated to be $2.8 trillion this year, is already too high. The growth rate in health spending is unsustainable." Their boycott, they add, "Is a step in the right direction—one of many we need to take."<br />
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<span class="s1">That <i>Times</i> op-ed was followed by a <a href="http://nymag.com/news/features/cancer-drugs-2013-10/">cover story in <i>New York</i> magazine</a> headlined, “The Cost of Living: New drugs could extend cancer patients’ lives—by days. At a cost of thousands and thousands of dollars. Prompting some doctors to refuse to use them.” </span><br />
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<span class="s1">We can say of both of these pieces, and the many others that followed: In the battle against cancer or aging, we need as many people involved as possible, even long before they get sick or retire. The cost of cancer drugs is a function of the high upfront cost to determine which drugs might work against which tumors in which people. Every data point, every person, we involve can lower that cost. </span><br />
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If some doctors believe that treating cancer on an incremental basis isn’t worth the cost, well, they should be reminded that the history of treating any disease—or, for that matter, the history of any technological advance—is replete with high upfront costs, followed by declining costs, and greater efficacy, as science progresses. To short circuit that process is a supreme instance of being penny-wise and pound-foolish. It allows the judgement of comparatively few skeptical researchers to be placed ahead of the collective benefit of great research. What gives some doctors the right to place their narrow perspective of the possible ahead of the public’s broader right to live longer, healthier lives?<br />
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The prototype of anything, we might observe, is ridiculously expensive. By definition, the new thing has no economic value--it's just a cost-center, someone's obsession. Yet if the concept proves out, and as production ramps up, prices naturally start to come down, as the product slides down the experience curve. That's how things that were unattainable at any cost--because they simply didn't exist--go from being, first, expensive luxuries, to second, inexpensive commodities, to third, unrecognizable, because some new innovation has come along to obsolesce the old thing. That's been the story of the Scientific and Industrial Revolutions over the last four centuries, and it's lifted up not only our standard of living, but also our lifespan. <br />
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So if we were to take seriously, as a society, the challenge of curing cancer, then we might consider new financing mechanisms, aimed at rewarding discoverers, innovators, and producers, and yet also making sure that the cancer drugs are widely available. But that's a topic for another post. </div>
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<span class="s1">So we come back to the lessons of Henrietta Lacks. Her case reminds us that scientific research does not always have an immediate "business model." Of course it doesn't: It's science. </span><br />
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The Lacks case also shows the that the gathering and sharing of human information simply must occur within an acceptable ethical framework. Most obviously, that ethical framework begins with the sine qua non of informed consent, which is so important that we find <a href="http://www.cancer.org/treatment/findingandpayingfortreatment/understandingfinancialandlegalmatters/informedconsent/">a lengthy discussion of informed consent</a> on the American Cancer Society website. </div>
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<span class="s1">Yes, it’s easy to imagine human information-gathering outside of an acceptable ethical framework. But it’s impossible to imagine such research staying secret for very long. And then there would be hell to pay. This is a world of social media, Twitter, and Instagram; information wants to be free. Indeed, even the government’s efforts to monitor all that information seems to quickly become public. </span></div>
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<span class="s1"></span><br /></div>
<div class="p2">
<span class="s1">So the only politically sustainable way to conduct breakthrough research is to explain to each individual the benefits and risks of participating, to create incentives for them to do so, and protections that information derived will not be held against them. </span></div>
<div class="p1">
<span class="s1"></span><br /></div>
<div class="p2">
<span class="s1">Perhaps in our big data age computers and algorithms will do most of the work. That is, ones and zeros will be the new white mice. That’s great, and will help reduce costs drastically, but sooner or later, any treatment will need human testing. The pool of human test-subjects could be drawn from desperate patients, or perhaps even compensated volunteers. But individuals and societies will have to to go in to the exercise with their eyes wide open. </span></div>
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<div class="p2">
<span class="s1">Who better than companies like Google to get people to share data and crunch it? No one, except giving tech companies your search history is very different than giving them your genetic data - the essence of who you are. Refining medicines, too, is much dicier than optimizing software. Web browsers have “back” arrows; bad code can be undone. Not humans. There’s no “Command Z,” or undo, when treatments go wrong.</span></div>
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<span class="s1"></span><br /></div>
<div class="p2">
<span class="s1">So even if computers become powerful enough to design drugs without lab work, researchers will need patients’ trust. Otherwise many who might benefit from trying a drug in a trial will say, “thanks, but no thanks.” A treatment that might have worked well in some will be written off as a failure, or dismissed by insurers and governments as having little value for the cost. That’s happening already, as we see in the <i>New York</i> magazine article cited above.</span></div>
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<div class="p2">
<span class="s1">Calico—and other similar efforts that are no doubt already ongoing—need to operate with the support of millions and maybe billions of people, sick and well. </span></div>
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<span class="s1"></span><br /></div>
<div class="p2">
<span class="s1">For big data and big science to work their wonders, each participant must feel personally connected to the research’s goal. After all, there’s much data that a healthy person could offer between now and when they fall ill that might help scientists detect their condition earlier and treat it better. </span></div>
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<span class="s1"></span><br /></div>
<div class="p2">
<span class="s1">That’s why politics matter. Every major gain in lifespan has followed a political and cultural shift in support of better science. This was true for vaccinations, safer childbirth, antibiotics, Franklin D. Roosevelt’s work on polio—the March of Dimes was a spectacularly successful public-private partnership—and recent efforts to cure HIV and eradicate malaria. Political support will matter even more in fighting age-related disease since effective treatment may have to start long before a condition is outwardly clear. </span></div>
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<span class="s1"></span><br /></div>
<div class="p2">
<span class="s1">Investments in real science, such as Page’s, are a welcome contrast to Washington DC’s belief that health issues can be solved solely by manipulating finance and insurance coverage. But for billionaire-funded “big science” to have lasting impact, funders must realign their interests with the public interest. Durable political coalitions rely on shared belief and coordinated action, not top-down brilliance. Once you earn people’s trust, you can ask them to lend their data, their voice, and eventually their lives; but trust comes first. That’s the enduring lesson of Henrietta Lacks. </span></div>
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<span class="s1"></span><br /></div>
<div class="p2">
<span class="s1">Indeed, we must never lose sight of the real glory that is humanity and human expression. As Pindar wrote 2500 years ago: </span></div>
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<span class="s1"></span><br /></div>
<div class="p2">
<span class="s1">“Creatures for a day! What is a man?</span></div>
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<span class="s1">What is he not? A dream of a shadow</span></div>
<div class="p2">
<span class="s1">Is our mortal being. But when there comes to men</span></div>
<div class="p2">
<span class="s1">A gleam of splendor given of heaven,</span></div>
<div class="p2">
<span class="s1">Then rests on them a light of glory</span></div>
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<span class="s1">And blessed are their days.”</span></div>
<div class="p1">
<span class="s1"></span><br /></div>
<div class="p2">
<span class="s1">Yes, we all are lit by the splendor given of heaven. And we should all have the right to participate in its glories. </span></div>
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<span class="s1"></span><br /></div>
<div class="p2">
<span class="s1">Today, we know longer fear The Fates, except as a metaphor. </span></div>
<br />
<div class="p2">
<span class="s1">Yet the common humanity that Pindar described is still with us. The shared radiance of collective purpose should shine down on all of us. If it does, we will all live longer, and better. </span><br />
<span class="s1"><br /></span>
<span class="s1">Editor's note: This piece was co-authored by Jeremy Shane and James P. Pinkerton.</span></div>
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James P. Pinkertonhttp://www.blogger.com/profile/06914344842339708576noreply@blogger.com1tag:blogger.com,1999:blog-5877221018800830362.post-71172660408708427122013-10-10T08:39:00.001-04:002013-10-11T16:05:26.497-04:00A hopeful headline--and a spur to action <div dir="ltr" style="text-align: left;" trbidi="on">
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<a href="http://4.bp.blogspot.com/-wqsaZgZH_JE/UlafK0dmSrI/AAAAAAAACLU/qhjEEtY1u_Y/s1600/Screen+Shot+2013-10-10+at+8.34.53+AM.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="247" src="http://4.bp.blogspot.com/-wqsaZgZH_JE/UlafK0dmSrI/AAAAAAAACLU/qhjEEtY1u_Y/s400/Screen+Shot+2013-10-10+at+8.34.53+AM.jpg" width="400" /></a></div>
<h1 class="title" style="color: #333333; font-weight: normal; margin: 0px 0px 5px; outline: none;">
<span style="font-family: inherit; font-size: small;">"Alzheimer’s treatment breakthrough: British scientists pave way for simple pill to cure disease"--that's the<a href="http://www.independent.co.uk/news/uk/home-news/alzheimers-treatment-breakthrough-british-scientists-pave-way-for-simple-pill-to-cure-disease-8869716.html"> headline</a> in <i>The Independent</i> (UK). </span></h1>
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<span style="font-family: inherit; font-size: small;"><br /></span></div>
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Then, the fine print, as it were: "Although the prospect of a pill for Alzheimer's remains a long way off, the landmark British study provides a major new pathway for future drug treatments." </div>
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And that should be our spur to action.<br />
<br />
UPDATE: Jeremy Shane, a long-time medical observer living in Washington DC, adds these sage comments:<br />
<br />
"First, it is critical for government funds to support ideas that seem out of the mainstream where mainstream ideas continue to disappoint. <br />
<div class="p1">
<br /></div>
<div class="p2">
"Second, figuring out a drug that "works" is only half the battle -- we need funds to figure out how to deliver drugs only to those places where they will be useful and not to places where they cause side-effects. </div>
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<br /></div>
<div class="p2">
"On the first point, Alzheimer's research for decades has focused on two competing causes of neuronal failure -- accumulation of beta-amyloid protein tangles or the malfunction of a neuronal protein called tau. AD, they agreed, seems to happen when neurons stop "taking out their trash." </div>
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<br /></div>
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"Then, along come a few out-of-the-mainstream scientists who look at the lack of real progress with either of these approaches, and say, you know, the way AD seems to spread in the brain sure looks like a prion disease, like Mad Cow's disease. It's fair to say mainstream AD researchers laughed at them. Certainly advocates of the prion idea got the Rodney Dangerfield treatment when it came to NIH grant applications. But little by little, the "prion-like" advocates piled up studies until brain imaging studies were able to show that AD spreads from one brain region to the next pathogenically, much like a prion disease (even if the scientists couldn't point to an actual prion protein causing it). </div>
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<br /></div>
<div class="p2">
"So here is this UK article on an AD breakthrough and the two main theories of how AD is caused, theories that have garnered tens of billions of research dollars, aren't even mentioned. What's more, it suggests to the reader that the prion thesis as a basis for AD research is pretty well established. </div>
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<br /></div>
<div class="p2">
"So, this is a good reminder that even science -- among scientists -- is political, and that consensus can -- must -- change when facts change. Facts win. So it is incumbent on funders, especially government funders, to create systems that allow unpopular ideas to get tested especially in areas like AD where time and again, consensus ideas yield paltry results. (NIH does have a EUREKA grants program that is supposed to fund these out of the mainstream ideas, but its funding is quite small in the larger scheme of things).</div>
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<br />
<div class="p2">
"Second, discovering new drugs -- like discovering new explosives in the military -- is a necessary first step. But they are of little value if you can't reliably deliver them on target without collateral damage. This work on AD reinforces that challenge -- for researchers and funders. This compound was delivered orally and was able to the brain. Great, but it also messed up other parts of the body. Drug delivery in AD -- finding new ways to deliver drugs directly into the brain and only the brain -- will be as important to a treatment's success as the active ingredient." </div>
</div>
</div>
James P. Pinkertonhttp://www.blogger.com/profile/06914344842339708576noreply@blogger.com12tag:blogger.com,1999:blog-5877221018800830362.post-46667471479965938382013-10-01T08:34:00.002-04:002013-10-01T08:34:44.675-04:00"Another Merck Reorg And Cutback: 8500 Jobs To Save $2.5 Billion" <div dir="ltr" style="text-align: left;" trbidi="on">
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<a href="http://3.bp.blogspot.com/-6b2OUfb2iKU/UkrA5KKQBjI/AAAAAAAACKI/J0TcmkU9gUg/s1600/Screen+Shot+2013-10-01+at+8.31.46+AM.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="276" src="http://3.bp.blogspot.com/-6b2OUfb2iKU/UkrA5KKQBjI/AAAAAAAACKI/J0TcmkU9gUg/s400/Screen+Shot+2013-10-01+at+8.31.46+AM.jpg" width="400" /></a></div>
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<a href="http://www.pharmalive.com/another-merck-reorg-and-cutback-8500-jobs-to-save-25-billion">More industry shrinkage</a>. </div>
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James P. Pinkertonhttp://www.blogger.com/profile/06914344842339708576noreply@blogger.com0tag:blogger.com,1999:blog-5877221018800830362.post-48878970036740564562013-09-21T08:01:00.000-04:002013-09-21T08:11:09.297-04:00This cartoon sums up today's healthcare policy <div dir="ltr" style="text-align: left;" trbidi="on">
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<a href="http://4.bp.blogspot.com/-hHFIZQnl8fk/Uj2KcbA4HiI/AAAAAAAACH8/439XII6qgYw/s1600/New+Yorker+-+cure.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="386" src="http://4.bp.blogspot.com/-hHFIZQnl8fk/Uj2KcbA4HiI/AAAAAAAACH8/439XII6qgYw/s400/New+Yorker+-+cure.jpg" width="400" /></a></div>
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James P. Pinkertonhttp://www.blogger.com/profile/06914344842339708576noreply@blogger.com2tag:blogger.com,1999:blog-5877221018800830362.post-47181981007287727602013-09-20T12:55:00.000-04:002013-09-20T12:56:57.323-04:00"Google vs. Death" and the Hamiltonian Framework <div dir="ltr" style="text-align: left;" trbidi="on">
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<a href="http://4.bp.blogspot.com/-C9k0Q7ktta0/Ujx7DvoiVcI/AAAAAAAACHk/wdaGts-rtJ8/s1600/frankenstein-castle-torch-wielding-mob.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="273" src="http://4.bp.blogspot.com/-C9k0Q7ktta0/Ujx7DvoiVcI/AAAAAAAACHk/wdaGts-rtJ8/s400/frankenstein-castle-torch-wielding-mob.jpg" width="400" /></a></div>
<div class="p1">
<span class="s1">The headline in <a href="http://content.time.com/time/magazine/article/0,9171,2152422,00.html%23ixzz2fS3HvBrY"><span class="s2"><i>Time</i> magazine</span></a> is certainly bold enough: “Google vs. DeathHow CEO Larry Page has transformed the search giant into a factory for moonshots. Our exclusive look at his boldest bet yet--to extend human life.” </span></div>
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<span class="s1">Yes, this is very interesting, and exciting, what Google/Calico has in mind. It’s great to see someone focusing on what really matters most in healthcare, which is medical cures. Insurance for sickness is great, but getting and staying healthy is greater. </span></div>
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<span class="s1">And the G/C folks may be so smart, so rich, and so focused that they can simply blow past all the obstacles that have stymied others. </span></div>
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<span class="s1"></span><br /></div>
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<span class="s1">But if G/C doesn't deal with public policy concerns about equity and economy, then it could well, too, end up stymied. For example, Gregory Ferenstein and Rip Epson of <a href="http://frankenstein%20torches%20castle/"><span class="s2">TechCrunch</span></a> raised some sharp questions in a piece bluntly titled “WTF Is Calico, And Why Does Google Think Its Mysterious New Company Can Defy Aging?” </span></div>
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<span class="s1"></span><br /></div>
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<span class="s1">The authors made it clear that they support, say, curing cancer, but at the same time, they questioned the use of resources, including fiscal resources (entitlement costs, for example), ignoring the poor, and the general perception of elitism, if not James Bond villain-ism. If those perceptions are not dealt with, then this effort will never achieve broad political support, except among a few eccentrics. And if it doesn't achieve broad political support, then I'm skeptical that it will never achieve its potential. The NGOs, trial lawyers, Naderites, and bureaucrats will all be lying in wait, waiting to ambush. </span></div>
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<span class="s1"></span><br /></div>
<div class="p1">
<span class="s1">Right now, G/C is being positioned as what it, in fact, seems to be: A few billionaires wanting to live forever. That’s all great--progress in the world often depends on visionaries, and egocentrism is a part of vision. </span><br />
<span class="s1"><br /></span>
<span class="s1">One could only wish that the late Steve Jobs, for example, had devoted more of his energy to the issue of longevity. Not only did Jobs himself have much to offer, but as Apple the company demonstrated, it’s perfectly possible to translate bold innovations and mass-distribute them into the larger consumer arena. Then we are all better off. <br />
<br />
Yet questions of life-and-death are so important that they have to be answered in ways that don’t shock the conscience of the public. Otherwise, the public/human instincts of egalitarianism, jealousy, suspicion, paranoia, and crab-bucketism will kick in, as countervailing forces. And they will be powerful countervailing forces. </span></div>
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<span class="s1">After all, perhaps the last form of human solidarity left is the equality of the grave. So yes, if the “peasants” sense a huge rupture in the social-moral order, they could once again grab their pitchforks, light their torches, and head up the hill to<a href="http://www.youtube.com/watch?v=qLvGnro4Cgw"><span class="s2"> Dr. Frankenstein’s laboratory</span></a>. </span></div>
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<span class="s1">Once again, if they can do this all on their own, then the lack of political cover won't matter. But in this hyper-pluralistic world, it's hard to pull off a big project without a lot of political involvement. </span></div>
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<span class="s1"></span><br /></div>
<div class="p1">
<span class="s1">Indeed, ever since Hamilton, big projects--from the canals to the railroads to the telephone network to Apollo to the Internet--have always needed political support. </span></div>
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<span class="s1"></span><br /></div>
<div class="p1">
<span class="s1">And I suspect, in the end, G/C will be no different. Just as Google found itself deeply entwined with the government within a decade of its creation, so G/C will find itself entwined, too. The difference is that G/C has gotten off on the wrong foot. </span></div>
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<br /><span class="s1"></span></div>
<div class="p1">
<span class="s1">So it will still need what every other big project has needed: a political shield, which can be described as the “Hamiltonian Framework.” That is, the system of political acceptance that allows the project to go forward. G/C will need that Framework eventually; it’s just that now it will have have to work harder to get it. </span></div>
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James P. Pinkertonhttp://www.blogger.com/profile/06914344842339708576noreply@blogger.com2tag:blogger.com,1999:blog-5877221018800830362.post-81361683338510527022013-09-17T07:34:00.002-04:002013-09-17T07:34:20.060-04:00Doctor Uses New Technology to "Re-Grow" Man's Finger <div dir="ltr" style="text-align: left;" trbidi="on">
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<a href="http://2.bp.blogspot.com/-ldCGokFvKKM/Ujg9_7h8WEI/AAAAAAAACHA/VfrtLC3m6-w/s1600/Screen+Shot+2013-09-17+at+7.32.14+AM.png" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="336" src="http://2.bp.blogspot.com/-ldCGokFvKKM/Ujg9_7h8WEI/AAAAAAAACHA/VfrtLC3m6-w/s400/Screen+Shot+2013-09-17+at+7.32.14+AM.png" width="400" /></a></div>
<a href="http://miami.cbslocal.com/2013/09/16/s-fl-doctor-uses-new-technology-to-re-grow-mans-finger/">CBS Miami has the story</a>. </div>
James P. Pinkertonhttp://www.blogger.com/profile/06914344842339708576noreply@blogger.com0tag:blogger.com,1999:blog-5877221018800830362.post-7579741396078105412013-09-08T08:40:00.002-04:002013-09-08T08:40:09.290-04:00Mike Huckabee: "How do we fix our health crisis? By focusing on cures, not merely insurance and treatment." <div dir="ltr" style="text-align: left;" trbidi="on">
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<a href="http://3.bp.blogspot.com/-VtzD8uh92Ik/Uixv1vJ9mNI/AAAAAAAACFo/EDiiekYJlgQ/s1600/Screen+Shot+2013-09-08+at+8.37.57+AM.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="280" src="http://3.bp.blogspot.com/-VtzD8uh92Ik/Uixv1vJ9mNI/AAAAAAAACFo/EDiiekYJlgQ/s400/Screen+Shot+2013-09-08+at+8.37.57+AM.jpg" width="400" /></a></div>
<a href="http://triblive.com/opinion/featuredcommentary/4640127-74/health-care-insurance#axzz2eInlR3hf">Mike Huckabee</a>, writing in <i>The Pittsburgh Tribune Review</i>. </div>
James P. Pinkertonhttp://www.blogger.com/profile/06914344842339708576noreply@blogger.com0tag:blogger.com,1999:blog-5877221018800830362.post-7395153896733372832013-08-25T21:35:00.000-04:002013-08-25T21:50:32.007-04:00Mike Huckabee Talks Cure Strategy <div dir="ltr" style="text-align: left;" trbidi="on">
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<a href="http://1.bp.blogspot.com/-4lllW_7ALQs/UhqrTc5lSfI/AAAAAAAACBU/8uwDclEFeFw/s1600/Screen+Shot+2013-08-25+at+9.11.12+PM.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="77" src="http://1.bp.blogspot.com/-4lllW_7ALQs/UhqrTc5lSfI/AAAAAAAACBU/8uwDclEFeFw/s400/Screen+Shot+2013-08-25+at+9.11.12+PM.jpg" width="400" /></a></div>
On his <a href="http://www.foxnews.com/on-air/huckabee/index.html">"Huckabee" show</a> on Fox News just now, Mike Huckabee said that we need an Apollo Program against disease, or a Manhattan Project. He didn't shy away from the issue of federal involvement--saying that yes, the government would have to invest more. But at the same time, he emphasized that if such investment--coupled with tort reform and other streamlining--could lead to health breakthroughs, it would pay for itself. After all, just about anything is cheaper than spending $1 trillion a year on Alzheimer's Disease by mid-century. <br />
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Speaking of illnesses such as Alzheimer's and diabetes and their costs, he asked, "Why don't we try to eliminate them?... It would be a magnificent effort. Not just treat disease, but eliminate it." Inspiring words. </div>
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<br /></div>
<div class="p2">
He added of such an effort, "Think about what it could do for the economy." That is, not just saving money for the government, health insurers, and individuals, but also creating jobs in new industries. </div>
<br />
To be sure, the whole hour of the "Huckabee" show was devoted to much more than just the Cure Strategy. The former Arkansas governor offered a broad-ranging critique of the status quo, citing his own experience as executive of his state's Medicaid and other public health programs.<br />
<br />
He sharply critiqued the Affordable Care Act, aka, Obamacare, and he emphasized the importance of healthier personal behavior and prevention. All important issues, to be sure.<br />
<br />
But most notably, he also introduced a new concept--a new concept, at least, to the political and policy world of Washington DC--and that is, cures. A cure is better than care. The Cure Strategy.<br />
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The Cure Strategy portions of the show appear at about 35 minutes into the hour--the show reruns tonight, Sunday, at 11 pm ET. And clips should soon be available on the Fox News site. <br />
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James P. Pinkertonhttp://www.blogger.com/profile/06914344842339708576noreply@blogger.com2tag:blogger.com,1999:blog-5877221018800830362.post-89191910488287424962013-08-24T08:11:00.000-04:002013-08-24T08:11:10.822-04:00Alzheimer's Dementia Time Bomb--How 'Bout a Proactive Strategy of Treatment and Cure? <div dir="ltr" style="text-align: left;" trbidi="on">
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<a href="http://2.bp.blogspot.com/-blM_lD6W6z8/UhihnfPnlQI/AAAAAAAAB-8/bZHLjrLfvmI/s1600/Screen+Shot+2013-08-24+at+8.03.39+AM.png" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="400" src="http://2.bp.blogspot.com/-blM_lD6W6z8/UhihnfPnlQI/AAAAAAAAB-8/bZHLjrLfvmI/s400/Screen+Shot+2013-08-24+at+8.03.39+AM.png" width="365" /></a></div>
If the ravages of Alzheimer's Disease are a humanitarian and financial "time bomb," as UK Health Secretary Jeremy Hunt <a href="http://www.telegraph.co.uk/health/elderhealth/10263247/Hunt-employers-burying-heads-in-sand-over-care-time-bomb.html">suggests</a>, then perhaps it would be worth a national/international focus on better treatments and cures. No matter what sort of financial arrangements are made, the impact is going to be catastrophic. A cure is cheaper--and, of course, better--than care. <br />
<br />
These points, from The Telegraph article, do, indeed, paint a dire picture. But the strategy of helping workers rearrange their work schedules to deal with eldercare issues seems inadequate to the overall challenge. <br />
<br />
We should be striving to do to AD what we did to polio: make it go away. That's an argument that is sadly unheard in political circles. </div>
James P. Pinkertonhttp://www.blogger.com/profile/06914344842339708576noreply@blogger.com3tag:blogger.com,1999:blog-5877221018800830362.post-30881651016245497482013-08-20T16:44:00.002-04:002013-08-20T16:48:02.572-04:00"The Immortality Financiers: The Billionaires Who Want to Live Forever"--But Just One Thing <div dir="ltr" style="text-align: left;" trbidi="on">
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<span class="s1">The tech billionaires listed in this <i><a href="http://www.thedailybeast.com/articles/2013/08/20/the-immortality-financiers-the-billionaires-who-want-to-live-forever.html">Daily Beast</a></i> article--including Larry Ellison, Sergey Brin, and Peter Thiel--might </span>find more success in their quest for immortality if that quest were more realistically defined.</div>
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That is, rather than shooting for the moon on immortality--with all the infinite moral and ethical quandaries that emerge therefrom--they might focus on a war against disease, including the as-of-now-invincible <a href="http://en.wikipedia.org/wiki/Hayflick_limit">Hayflick Limit</a>, which casts a dark pall on any bright hopes for significantly longer life. </div>
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If so, then the optics of the struggle would shift from private to public. That is, the better-health/longer-life issue should shift from private vanity to public policy. And that's good news, ultimately, for all concerned. </div>
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<span class="s1">While a billionaire-boutique effort might be better than nothing--and as argued here many times, the drying up of the medical-cure pipeline is a serious and budget-busting issue--a true public-private partnership and a national or international mobilization beats everything else. </span></div>
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The bigger the better. Scale is your friend. </div>
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The billion-and-first iPhone is better--and certainly more reliable--than the prototype of something different, no matter how grand its ambitions. </div>
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<span class="s1">As we were reminded with Mitt Romney's Orca get-out-the-vote program, one doesn't want to be the first to use something complicated and technical. I would feel safer riding in a plane from Boeing--backed by a century of R&D, much of it financed by the Pentagon, as well as many millions of pilot hours--than in some contraption that just came out of the skunkworks. Thrill-seekers and would-be record-breakers can get in anything they want, of course, but they know the dangers. And the statistics confirm that such dare-devilry is, indeed, dangerous. </span></div>
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<span class="s1">If Ellison, or any of these others, is willing to be the very first person to try the new potion, well, that's okay. But the moment that he gets into testing it on anyone else--be it duped Third World peasants, unwilling Chinese prisoners, or even highly paid volunteers--that's when the trouble will come. Issues of right aside, this is an NGO world, and an NGO world with cellphone cameras and Twitter. </span></div>
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<span class="s1">So billionaires are best off learning from the successes of the past. If they study history, they will realize that the best way to truly get this done is the way the railroads got their way in the 19th century, or AT&T got its way in the early 20th century--or the polio vaccine in the mid-20th century. That is, by building a robust political framework around their enterprise, shielding them from liability, rent-seekers, etc. </span></div>
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<span class="s1">That's the time-tested way to get this done. I argued this historical point<a href="http://www.theamericanconservative.com/articles/bring-back-vannevar-bush/"> here</a>, on August 2. </span></div>
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James P. Pinkertonhttp://www.blogger.com/profile/06914344842339708576noreply@blogger.com1tag:blogger.com,1999:blog-5877221018800830362.post-17903560002841514642013-08-18T20:37:00.001-04:002013-08-18T20:41:33.424-04:00George Will on the Cure Strategy <div dir="ltr" style="text-align: left;" trbidi="on">
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<a href="http://www.washingtonpost.com/opinions/george-will-the-sequester--a-public-health-hazard/2013/08/16/4bb96982-05ca-11e3-9259-e2aafe5a5f84_story.html">George Will writes</a>:<br />
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<span class="s1"><b>For <a href="http://www.nih.gov/about/director/directorbio.htm"><span class="s2">Francis Collins</span></a>, being the NIH’s director is a daily experience of exhilaration and dismay. In the past 40 years, he says, heart attacks and strokes have declined 60 percent and 70 percent, respectively. Cancer deaths are down 15 percent in 15 years. An AIDS diagnosis is no longer a death sentence. Researchers are on the trail of <a href="http://www.fda.gov/BiologicsBloodVaccines/ScienceResearch/ucm353397.htm"><span class="s2">a universal flu vaccine</span></a>, based on new understandings of the influenza virus and the human immune system. Chemotherapy was invented here — and it is being replaced by treatments developed here. Yet the pace of public health advances, Collins says, is being slowed by the sequester.</b></span></div>
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<span class="s1"><b>He entered federal service to oversee decoding of the human genome, which he describes as “reading out the instruction book for human beings.” We are, he says, at the dawn of the era of “precision medicine,” of treatments personalized for patients’ genetic makeups.</b></span></div>
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<span class="s1"><b>This will be, Collins believes, “the century of biology.” Other countries have “read our playbook,” seeing how biomedical research can reduce health costs, produce jobs and enhance competitiveness. Meanwhile, America’s great research universities award advanced degrees to young scientists from abroad, and then irrational immigration policy compels them to leave and add value to other countries. And now the sequester discourages and disperses scientific talent.</b></span></div>
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<span class="s1"><b>In the private sector, where investors expect a quick turnaround, it is difficult to find dollars for a 10-year program. The public sector, however, with its different time horizon, can fund for the long term, thereby drawing young scientists into career trajectories and collaborations impossible elsewhere.</b></span><br />
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<span style="font-family: inherit;">We might note in particular the point that "<span style="background-color: white; line-height: 22.5px;">Other countries have 'read our playbook,' seeing how biomedical research can reduce health costs, produce jobs and enhance competitiveness." </span></span></div>
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James P. Pinkertonhttp://www.blogger.com/profile/06914344842339708576noreply@blogger.com1tag:blogger.com,1999:blog-5877221018800830362.post-5135615947653637082013-08-11T21:39:00.001-04:002013-08-11T21:50:53.685-04:003-D Printing: "Robohand" and the Future of Prosthetics <div dir="ltr" style="text-align: left;" trbidi="on">
A visit to the <a href="http://www.makerbot.com/retail-store/">Makerbot retail store</a> in Manhattan is an eye-opener, even for those who have been following the rise of 3-D printing over the last few years. One can see--and touch--the dimensions of new breakthroughs in prosthetics (to say nothing of any other gave of physical object that might be manufactured). <br />
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<a href="http://www.makerbot.com/">Makerbot</a>, headquartered in Brooklyn, has been around for a while, but it has chosen to create a showcase for itself in the East Village. That's good, because now more people will see the potential of 3-D printing, including its potential for medical devices. </div>
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Take a look at this "Robohand," or prosthetic hand, for example, pictured below:</div>
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The basic design was created by a man who had lost his hand, and, well, wanted another one. So here it is: all the parts here were made by a 3-D printer, except for the bolts (which could be made by 3-D), and the cords. It's functional and capable of grasping. </div>
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So how much did it cost? The machine to make it, from Makerbot, is $2200. The material, the filament, is about $2. The CAD/CAM software is free, one of thousands of such free programs from <a href="http://www.thingiverse.com/">Thingiverse</a>. </div>
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We might ask: What will this same project look like a year from now? And how much will it cost? We all know the answer--if we allow this new technology to advance. <br />
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And of course, that advance is vital for many, including our Wounded Warriors, to whom we owe so much. <a href="http://www.washingtonpost.com/business/economy/obama-announces-aid-initiative-to-help-wounded-veterans/2013/08/10/7ed6190c-01f4-11e3-9a3e-916de805f65d_story.html">President Obama recently announced an additional $100 million for medical research and treatment</a>; 3-D printing of prosthetics helps us see how that money could make a difference--not just for the benefit of Wounded Warriors, not just for anyone else in need of prosthetics, but also for the huge new industry now on the horizon. Doing good and doing well--that's the magical combination of the industrial revolution and mass production. <br />
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Here's another picture of another prosthetic device, alas, not as clear. </div>
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And here, for what it's worth, is a picture of the description of the process by which this "Robohand" was made. </div>
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Much more, of course, to be found on the Makerbot websites. </div>
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The future is, indeed, bright. </div>
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James P. Pinkertonhttp://www.blogger.com/profile/06914344842339708576noreply@blogger.com0tag:blogger.com,1999:blog-5877221018800830362.post-49023685780790090692013-08-01T20:16:00.001-04:002013-08-01T20:16:11.391-04:00The Needed Framework for Cures <div dir="ltr" style="text-align: left;" trbidi="on">
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Gillian Tett's <a href="http://www.ft.com/intl/cms/s/0/9cdfdeca-f938-11e2-86e1-00144feabdc0.html#axzz2alL9nAgT">thought-provoking article</a> in the <i>FT </i>points to a looming problem--the public could be losing confidence in "Big Data"-ish strategies, even when they have nothing to do with the National Security Agency. <br />
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In particular wide-scale biomedical research will be caught in the downdraft of public anxiety over spying and privacy.<br /><br />It's an interesting point, and Tett cites two possible solutions: private data centers, in which the data is anonymized, and popular subscription campaigns. <br />
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Both are worthy suggestions, but it's clear that nothing will work amidst public cynicism, skepticism, and even hostility. <br />
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It's going to take political leadership--backed up by leadership from other sectors across all of society--to reinstill public confidence.<br />
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That is, it's going to take a framework, not unlike that which the federal government created around infrastructure projects, such as canals and railroads, in the 19th century. Or around the telephone, television, and Internet networks of the 20th century. </div>
James P. Pinkertonhttp://www.blogger.com/profile/06914344842339708576noreply@blogger.com1